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Monday, October 30, 2017 11:34:13 PM
If everybody crosses over upon progression (X-Over = 100% on my chart) it should be obvious that the entire 33 who never received DCVax-L must be progression free
Actually if you take a look at the SSF 2016 presentation slide on ITT stat population, you would clearly get that your assumption is simply wrong. In those that were not treated with Dcvax there's an unknown number of ppl that had progression/recurrence then went onto other treatments. Of those now assumed 10% who at the time of Asco presentation did not receive the drug, it must be similarly counted those ppl subgroup, too. How many of them were PFS with no treatment and how many were PFS with treatment other than Dcvax after progression? There's no way to know. IMO certainty is that the subgroups of placebo PFS might indeed be very very small, thus the 'we are comparing dcvax early with dcvax late' and the IMO closer look at OS at this point.
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