Here is a breakdown in layman terms of the presentation data:
Page 4: These are the photos of the hearts showing that TVEMF prevented or reduced the heart from enlarging following MI. The control hearts on the left are visibly much larger than the ones treated with TVEMF.
Page 5: This chart demonstrates the heart-weight-to-body-weight ratio (HW/BW), which is an index for hypertrophy (growth of the heart). As seen the HW/BW of the control is significantly larger than HW/BW ratio for those treated with TVEMF.
Page 6: LVDP = Left Ventricular Diastolic Pressure, which is a measurement of blood pressure within the ventricle. This is showing that TVEMF treatment significantly increase the contraction of the heart as evidenced by more blood pressure during the contraction. After MI, the heart is weak. The chart on the right is this measurement in relation to time (time derivative).
Page 7: Fractional Shortening = simply put is the shortening of the end-diastolic diameter that occurs by the end of systole (contraction). Ventricular diastole is the period during which the ventricles are filling and relaxing. So a higher fractional shortening allows more blood flow. If the diameter fails to shorten by at least 28%, the efficiency of the heart in ejecting blood is impaired. We can see from the chart that the control group had impaired FS and that TVEMF treatment significantly increases FS.
Ejection Fraction = the fraction of all blood in the ventricle that is ejected at each heart beat. The normal EF of the left ventricle is 65%, I don't know what it is for mice, but should be similar. The chart shows that the control group had very significant reduction of EF and that TVEMF treated animals had significantly higher EF, which is improved heart function and blood flow.
Page 8: left ventricular end-systolic diameter is measured at end systole (contraction). It corresponds to the smallest cardiac dimension. LVESD is a marker of left ventricular function. Following MI, the ventricle will be dilated and reduce contraction and blood ejection. Based on the chart TVEMF significantly reduced dilation of the left ventricle.
Page 9: This shows there was repair to the septum measured at the end of contraction. A thicker interventricular septal thickness measured at systole equates to a heart function and repair.
So all in all, we good results. Can't wait until tomorrow to see what will happen once the news has been digested over the weekend. Looking forward to stealing day trader shares.
