Amarin Corp Plc (AMRN)

[staccani]

Re: EPA intake effect of AA reduction (hence the double effect of Vascepa on both the numerator and denominator of the AA/EPA ratio)


13.2. Anti-Inflammatory Nutrients

The omega-3 fatty acid eicosapentaenoic acid (EPA) will have little direct impact on the reduction of AA because it is a weak inhibitor of the delta 5-desaturase enzyme; however, at high dietary intakes, the EPA can dilute out the concentration of AA in the cell membrane thereby decreasing its potential of being converted into a pro-inflammatory eicosanoids, such as leukotrienes. As stated earlier, high intakes of EPA can also reduce inflammation in the adipose tissue [70–72]. Thus by either directly inhibiting the formation of AA or diluting it out by the presence of high levels of EPA in target cells (especially in the adipose tissue), overall inflammation will be automatically reduced as long there is constant supplementation with fish oils rich in EPA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952901/