Anavex Life Sciences Corp (AVXL)

[sliceanddice59]

I would say that 100% of drugs that targeted amyloid plaque failed. To my knowledge, none of the 4 drugs approved by the FDA for AD targeted amyloid plaque.

As has been posted before, 99.6% of all drugs tested for AD have failed. This means that 0.4% of these drugs were successful and were FDA approved. According to Missling and others, only 4 drugs have ever been approved by the FDA for AD. So 4 drugs represents 0.4% of all drugs tested. This means that only about 1000 drugs have been tested. It has also been posted a number of times that only 2% of incepted compounds made it to P3. So, 2% of 1000 is 20 compounds that made it to P3. Of these 20 compounds, 4 were FDA approved. This is an approval percentage of 20% for those drugs that made it to P3.