If there were contradictory or simply non supportive factual information on the CNS restorative/regenerative possibilities of A2-73 I would be less positive. If we were having debates about one scientific school of thought vs another (possible/not possible) then I would be listening/concerned. But there is non of that. A lot of smart people would like to blow the whole thesis to bits but not a peep of factual argument. What we have are endless "he said-she said" BS trivia which is fundamentally pointless IMO.
We now see today that the new Director of the FDA is saying basically the same thing that Dr. M. has been saying for a long time...he is saying that is the direction the FDA are headed in. He did not say AVXL is a brilliant solution but he also did not say "More Plaque research is the answer" either. He did say it is possible there is another "bacteria" level of new world breakthrough out there and he is looking for it vs keep doing more of the same. He is ready to acknowledge it.
I am still connecting the dots as I see them. I see Red, Falcon, Jimmy, Iceberg, bear, dad and others who are pretty damn capable people (to the extent I am qualified to judge)biased possibly but not stupid enough to let that bias drive their investment. We want this to work and will keep connecting the dots. IMO, now that the FDA has come out showing some cards we will see things start to happen faster. As soon as some credible contradictory data presents on CNS homeostasis being a non possibility and possibly the thesis cannot be proven.
Last point would be to evaluate what has been done over the passed 20+ years with the benefit of hindsight. No AD patient ever stabilized or got better/recovered....ever, kids still have Rett, people still have PD, MS...etc. That is just wrong. More of the same would be wrong.
