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Monday, 09/04/2017 10:21:52 AM

Monday, September 04, 2017 10:21:52 AM

Post# of 464083
Anavex Better Than Senolytics? Anavex Antisenescent Drugs?

A new treatment approach to senility and aging is beginning to emerge, the use of “senolytics,” drugs that destroy (“-lytic”) senescent, old, non-functioning cells.

With these, it is hoped or presumed, senility and the related debilities of aging will be obviated, getting rid of old, non-functioning cells, leaving in place yet-functioning cells.

Here’s an article on the matter at the Mayo Clinic:
https://www.eurekalert.org/pub_releases/2017-09/mc-mcr_1083117.php

Should this technology mature and prove useful, all well and good.

I would suggest that Anavex Life Science Corp has in their pipeline molecules that might prove even better. Instead of destroying old, poorly- or non-functioning brain cells, Anavex molecules restore them to a more youthful function status. No loss of brain cells. No volumes of dead cell tissues and compounds to eliminate.

Might Anavex molecules prove to be “antisenescents,” drugs that keep nerve and brain (or other) cells from aging and dying?

Might anti-aging pharmacotherapies be in the Anavex armamentarium?

Anavex 2-73 is known to put back together dislodged or disconnected organelles in neurons, and the binding targets of the Anavex molecule that allow this, the sigma-1 receptors, are in the cells of most other body systems. Good reason to hypothesize Anavex sigma-1 receptor agonists might be able to restore normal, youthful functions, the homeostatic state, in a variety of cells and organs, not just nerve and brain cells.

Antisenenscence. The delay and suppression of cellular and organ system aging. Might Anavex Life Science Corp eventually lead the way?


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