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Re: falconer66a post# 117782

Tuesday, 08/29/2017 8:45:15 PM

Tuesday, August 29, 2017 8:45:15 PM

Post# of 459535
Another Big Potential
DMA Duchenne's muscular Dystropy, caused by recessive X21 gene.

DMD is caused by a mutation of the dystrophin gene at locus Xp21, located on the short arm of the X chromosome.[7] Dystrophin is responsible for connecting the cytoskeleton of each muscle fiber to the underlying basal lamina (extracellular matrix), through a protein complex containing many subunits. The absence of dystrophin permits excess calcium to penetrate the sarcolemma (the cell membrane).[8] Alterations in calcium and signalling pathways cause water to enter into the mitochondria, which then burst.

Kind of sounds like it might be right up our alley:)If our drug can bypass the mutation and return cells to Homoeostasis, balancing CA+, preventing water from entering mitochondria, maybe we have a winner.
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