NorthWest Biotherapeutics Inc (NWBO)

[chinatown1980]

Seems like there is still a lot of confusion on the board regarding median OS. Let's start with the basics. When the trial reads out, is the reported mOS based on the group of actual patient events (say median of the 233 recorded events if unblinded then), or is it the estimated median survival of the entire trial group of 331 (so the 165/166 rankings) with the KM technique applied to account for events that have not actually occurred or been recorded (LTFU, etc.,)?

If it is the latter, and the remaining patients alive have all exceeded the survival time of the current 165/166 events in rank order, then shouldn't the median remain static going forward as additional events would be plotted to the right of 166 on the curve all the way out to 331?