NorthWest Biotherapeutics Inc (NWBO)

[wavelengthy]

Erin Dunbar
March 2017
Director of Neuro-Oncology at Piedmont Brain Tumor Center: Science and new technology are helping to provide patients with better prognoses while minimizing treatment side effects. You will learn about the latest treatments for brain tumors including: promising drug therapies, new device and cutting-edge options now available.

"Another example are clinical trials that we have here and elsewhere that actually take people's tumor tissues out and actually then take it with their own individual immune their immune cells and make an individualized vaccine that we can give back to the patient with their own immune system cells fighting their own individual tumor"

segment 1a:

"...how to know when to combine them. and so a few examples and one that everyone has heard about is immune therapy so let me share in my own words how I put that together. I think of the immune system it's much like our Special Forces our Armed Forces Army Navy Air Force Marine it could be the different types of white blood cells and the different types of cells that we have as immune fighters in our body and what the immune system is challenged to do every day whether it's a rusty nail in our finger or or a virus or a tumor cell is to be able to identify an offender, not a "self" cell, but an offender, an unwelcomed offender then to be able to present it to the people that can do something about it - the effector cells like t-cells then to develop a specialized response to that offender, magnify and optimize that fight and just as importantly know when to quit, know when to turn it down and that's really what the immune system is doing and that's what immunotherapy and tumors are trying to do.

And so let me give you a few examples because they're important, and they often require tissue, and they require testing to be able to utilize. This is an example: CTL-A is a receptor and what that receptor is a break, a natural break on our T cells that mandate that we have a double check system to make sure that we have a CO-stimulation of our T cells before they really know it's an offender and they really want to start a fight. What we what that does is actually we it's like a brake system so by blocking that brake or putting an antibody on that brake we can unmask the T cells to better recognize the offending tumor and unleash that tumor treatment"

segment 1b:

2.
See 2:00-2:23 (link below) for a treatment outlook according to DCVax Investigator, Dr. Daniela Bota's (Director of UC Irvine’s Comprehensive Brain Tumor Program):

“This is like watching a horse race,” says Bota. “We know that one of those horses is going to cross the finish line. It’s going to happen. The most important thing that we can do is ask our patients to please take part in clinical trails.”

CBS Jul 20, 2017:
http://losangeles.cbslocal.com/2017/07/20/understanding-aggressive-brain-tumor-john-mccain-is-battling/



3. Additional perspective from UC Irvine's Dr. Daniela Bota - published Dec 30, 2016
“There are few things that we are involved on at University of California-irvine. We've been involved on those projects for years, some of them right now are coming to fruition and they're transforming themselves on FDA approved treatments. Others are in different other stages of research either in our laboratories in cells and animal models or they are right now applied to patients in clinical trials. So the first step that we have to discuss again personalized medicine”.

link: