NorthWest Biotherapeutics Inc (NWBO)

[kabunushi]

I'm still learning what everything in these K-M curve models mean, esp wrt censored patients, so pls forgive some really basic questions - e.g. are the censored completely omitted from the curves or are they recorded on the curve from the start until the date they are censored (in your model the censored asof dates would have to be randomly or uniformly distributed I guess)?

One reason I'm trying to understand exactly how the censoring influences the curves is that I notice about your model that wrt the number censored, you have a much lower % of the placebo arm as censored (23/110) vs the % censored in the treatment arm. (80/221). Why is that? In general what effect would having more or fewer patients as censored have the KM curve or on the mOS predictions?

Thanks for your patience in helping me understand this if you can.

Stratum Total observed Total failed Total censored Time steps
1 DCVAX-L 221 141 80 164
2 PLACEBO 110 87 23 79