NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Thank you Longfellow: (and Doc Logic): That PR was a very big deal yet I had forgotten much of it. Not entirely clear to me whether"controlling" mesenchymal and methylation necessarily allows subgroup SS as a fallback without a statistical threshold hit / alpha spend... but it might have been taken into account already.

Those stats on the permanent immune system damage from radiation are extremely disturbing. I am not going back on the bandwagon saying skip SOC... as I would have a couple years ago when I thought I knew by butt from..., but holy moly, 40% of patients with immune systems irreversibly destroyed... wow! Certainly begs research into any changes that might improve that stat if immunotherapies are to become part of the solution. I know there are super expensive types of radiation with far less collateral damage, but I do not remember damage to the immune system being mentioned as part of the improvement. I hope it is. Avoid penetrating the bones??? Be full of anti-oxidants during treatment so that only more directly hit areas have sufficient free-radical density to kill stuff???? Hopefully all optimized in the past, but the equations change when you add an immunotherapy.

The one part of SOC that I return to B&Ming about is using temalozine on patients/tumors that are not methylated. (I am sure not quite right usage of the term). This concern because TMZ is known to sometimes damage the immune system. But... apparently not the dominant concern regarding the immune system, and perhaps fear of inhomogeneity and real-time mutation force the hand toward usage of TMZ regardless of methylation. Or was/is it just marketing?