Anavex Life Sciences Corp (AVXL)

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Azeliragon Merely Slows Alzheimer’s Decline, Anavex Stops It

I just read the announcement of the Phase 2b clinical trial of Azeliragon, a new Alzheimer’s drug, with a unique mechanism of action. It’s not a sigma-1 receptor agonist (only Anavex has those), nor an acetylcholinesterase inhibitor, nor an immunological waste protein clearance drug. It blocks the receptor RAGE (Receptor for Advanced Glycation Endproducts) in the brain, thereby slowing cognitive decline.

But, apparently that’s all that really happens, symptomatically. Like the acetylcholinesterase inhibitors, the new drug merely slows cognitive decline; perhaps better than existing drugs; but it will be no competition for Anavex 2-73, which either maintains cognition or actually improves it.

There were also compounding side effects with the drug, at higher doses. Anavex 2-73 has none of those (merely very mild Level 1 and 2 side effects).

https://alzheimersnewstoday.com/2016/07/29/vtv-therapeutics-azeliragon-slowed-cognitive-decline-in-mild-alzheimers-disease/