NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Edit: What I might do if I were an 80 year old public figure with unlimited funds diagnosed with GBM to help push the science in a right to try state.

First, I'd make certain the tumor was saved, and a small amount of it biopsied for tumor type.

I'd undergo leukapheresis.

Next, if the tumor type was methylated MGMT, I'd not skip chemoradiation, but would strongly consider a shorter course (because of age) -- if Doctors agreed.

However, if my tumor was not methylated MGMT, I'd skip chemotherapy completely -- if my doctors agreed.

If my tumor was not methylated and my absolute lymphocyte count was extremely low, I'd not only skip chemoradiation, I'd also consider truncating radiation dramatically -- if my doctors agreed.

If my tumor type was either EGFRIII positive and/or HLA-A2+; and after the above took place, I'd immediately start one and/or both therapies - aka: Rintega and/or ICT-107- if my doctors agreed.

Once DCVax-L manufactured, I'd concurrently, ASAP, add DCVax-L therapy systemic subdermal doses, concurrent with regionally injected small doses of antiPD1 -- if my doctors agreed. (I might additionally ask if the doctors could also combine a small amount of anti-PD1 in the same syringe as DCVax-L.) -- if my doctors agreed.

I would follow all medical recommendations to increase my lymphocyte count every step of the way -- if my doctors agreed.

I would additionally seriously contemplate adjuvant hyperthermia treatments to the extent I could safely tolerate it -- if my doctors agreed.

If the cancer returned I would continue with the same, remove new tumor for new biopsy and to make new batch of DCVax-L; go through the decision making steps above again, but additionally add CTLA-4 injected regionally, and PLX-3397. -- if my doctors agreed.