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Re: jfmcrr post# 110485

Thursday, 07/20/2017 4:17:41 PM

Thursday, July 20, 2017 4:17:41 PM

Post# of 425913
jmf,
"I expect that the safety profile of V is a given".

I believe that to be true, but I certainly would not expect the DMC to make that assumption.

"the object of the exercise is proportion of events per group"

To know that you would have to start keeping track because on a quarterly basis, they are not going to be proportional. I would think on a quarterly basis, they only look at events in that quarter only. They are not keeping a scorecard.

"It is watching for an anomalous distribution of deaths among the expected deaths."

There would have to be a lot of assumptions baked in to do that. We can't even agree on a proper placebo rate on this board, but the DMC can figure it out by proportions? I just don't see it any other way than what I have previously stated.
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