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Re: A deleted message

Monday, 07/17/2017 10:19:05 PM

Monday, July 17, 2017 10:19:05 PM

Post# of 462237
I have invested in AVXL since Jun 2015 - pre-split so have seen all the hype around the trial etc.

With all the hype - the only trial we have seen till now is the old 32 patient trial. Everything else is just talk. So I am skeptical and will not stop questioning till I see actual progress.

I have seen too many trials that take way longer than what has been anticipated or promised. Trials involving kids are much tough and take much longer. The enrollment in trials is much slower in case of CNS diseases compared to other areas - simply because they are tough and population is not concentrated.

We have less than 6 months till end of Dec - the trial is 3 month duration - so to even complete 3 months for all patients - the enrollment has to finish end of Sept

The co has not published pk/pd data - then trial protocol submission to fda - upto 60 days for fda approval to start trial - then site mobilization - start of screening and 1st patient enrollment

Add all the time together and you have Sept/Oct just to start enrollment.

Think logically - look at other cns trials and try to justify your Dec timeline and then call me negative person.

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