re: "Perhaps the ApoE4 gene provided a survival advantage in ancient environments. Today only about a quarter of us have a single copy of the ApoE4 gene, and only about two in a hundred carry a double dose. But DNA analysis of ancient bones shows that thousands of years ago, the ApoE4 genotype was ubiquitous in humans. The gene — which helps to generate cholesterol — might have been a crucial step in the development of our big, energy-hungry brains, and it may have played a key role in defending those brains from pathogenic invaders."
In case an additional opinion on the article may be of interest.:
In a previous post, I noted that Innuits have no AD and theorized that it may be due to their "Paleo" diet. Basically this refers to the Paleolithic prehistoric era wherein our ancestors mainly ate meat, and little else. The Tsimane tribe also appears to derive most of their nutrition from hunting. Besides fairing better in regard to CNS disease, the researchers found that the Tsimane "have the cleanest arteries of any population that has ever been studied, meaning that they may be largely immune to heart disease."
The researchers see a possible link to them having certain parasites in their systems. Well. Maybe. But one thing we haven't really covered in any discussion I've seen so far is, what picks up the S1 receptor naturally? The corollary being that it isn't being triggered properly when needed in modern civilization humans, probably due to our necessity of eating mass produced food. I'm thinking the high lectin load in popular carbohydrates being pushed as "healthy", not to mention sugar, various chemicals like Roundup showing up in everything from baby formula to vaccines...
The phrase, "a key role in defending those brains from pathogenic invaders." may be the gene and/or response to parasites but, somehow the natural S1 triggering/modulation protocol is being dusrupted. Giving the S1 receptor constellation a little help (via 2-73) would explain the dramatic "unexpectedly" positive results seen thus far. It also appears that not just any S1 agonist will do.
I'm not about to give up my favorite modern foods any more than I would want wild parasites (there seems to be a friend or foe situation with that). Even if one can achieve the right stuff in their gut it's likely the S1 system is still being screwed up by a constant input of negative influences and thusly still benefits from the delicate antidote effects of 2-73.
It is also a bit irksome that the article ends with apparent obligatory pumping of amyloid obliteration even though the researchers report wasn't about that. I suppose we'll have to keep expecting information for public consumption to be "managed" in favor of entrenched paradigms. At least for a while yet here. https://www.nytimes.com/2017/07/14/opinion/sunday/alzheimers-cure-south-america.html