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Sunday, July 02, 2017 1:31:52 PM
1) I recently asked AVII his opinion on the scenario where PFS fails but OS wins. I wasn't asking that because I thought PFS failed.
2) If there were a swarm of pseudoprogressors, then they were likely induced by DCVax-L soon after treatment. If so, it would be a mistake to characterize them as having slipped through the screening. But such could certainly give PFS a false failure if they are mistaken as true progressors. The post analysis, however, would be very interesting. One would see any such mistaken progressors from the treatment group with super long OS. That would beg consideration... beyond beg.
3) Due to circumstances beyond my self-control I am currently quite poor. For that reason I am not all-in. For that reason it pains me to post anything positive. So... I will not do so often until I hit the Lotto. That said, I am not at all sure that DCVax-L will prove out. I just think the risk-reward is very compelling, and the story and potential in the medical sense are compelling. But then I was a cheerleader here for years before becoming a broken mute so of course I want this trial to end well.
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