Amarin Corp Plc (AMRN)

[AVII77]

I would like a logical dispute of my previous post.

How about this:

when you look at KM curves for high risk patients (say Improve-IT for exmple) you see the event rate decreasing with time. (that trial enrolled patients within 1 month of a major cardiac event and those folks tend to die. If they make it past their first year, their risk decreases (the event rate decreases).

Then consider Emphasis-HF in mild heart failure. You see the same increased risk soon after randomization and then it stabilizes. It is a muted version of Improve-IT because the patients are not "as sick". but the rate decreases over time.

Contrast that with a low risk group like the Womens Health Study looking at aspirin. There you see the event rate increasing with time. Likely due to age. But it was a very long study.

We are somewhere in between. Other similar trials (ACCORD for example) showed a pretty constant event rate.


also remember (in terms of timing how long it takes to go from, say 80% to 100% of events),

While it is true event rate will increase with age ....

...it is also true that as people event they are removed from the population at risk for a first event.

And all this is not to say you are wrong. Just a different view. Hopefully a "logical dispute" if you will. You may be right.
KM curves below.

Improve-it



Emphasis-HF


accord


womens health study