Anavex Life Sciences Corp (AVXL)

[blu_1]

Interestingly, with the two ladies from the trial highlighted on Aussie TV, they were interviewed at 8-9 months into the trial. The man they showed on TV, I'm not sure for how he had been on 273, 8 mos to a year I think. I think when all 3 were interviewed they hadn't yet started to slide back down after making improvement. Whereas with donepezil, patients start to slide back down after 3-4 months and after 6 months, they've usually dipped below baseline and just keep falling.

Of the 7 dropouts, I know at least several complained of neuro issues (I think those included: dizziness, disorientation, headache, concentration problems). Whether those symptoms were related to the drug or not, IDK. I'm not sure why they dropped out. Perhaps they were on too high a dosage given their body type, physiology, comorbidities, age, and sex? I think administered dose strengths spanned from 10mg to 50mg. It was determined 14mg was the minimum therapeutic dose. Doubt anyone will be on that or lower for Ph 3.