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Thursday, May 04, 2017 10:51:54 PM
Data listed under the description tab and comes from the anti-seizure patent: (EN) A 19-144, A2-73 AND CERTAIN ANTICHOLINESTERASE INHIBITOR COMPOSITIONS AND METHOD FOR ANTI-SEIZURE THERAPY
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016064711&recNum=1&maxRec=&office=&prevFilter=&sortOption=&queryString=&tab=PCTDescription
Example 1
Seizure Prophylaxis: A19-144
A 13 year old male is experiencing 4 to 7 seizures per day with a baseline of 6.6 seizures per day. A19-144 is administered daily at 2.0 mg for 5 days. Seizures reduce to 2.2 per day for 8 weeks post dosing.
Example 2
Seizure Prophylaxis: A19-144 and Donepezil
The 13 year old male of example 1 is experiencing seizures at 2.2 per day at 6 months post dosing as stated in Example 1 . The subject is administered low dose donepezil (4mg daily) for 5 days cotimely with continued A19-144 administration daily at 2.0 mg for 5 days. No seizures are detected at 6 months post dosing. Cognitive testing detects no diminution of memory as compared with the subject prior to donepezil administration.
Example 3
Seizure Prophylaxis: A19-144
A 57 year old female is experiencing 6 to 8 seizures per day with a baseline of 6.6 seizures per day. A19-144 is administered daily at 2.0 mg for 5 days. Seizures reduce to 1 .2 per day for 8 weeks post dosing.
Example 4
Seizure Prophylaxis: A19-144 and Eslicarbazepine acetate
The 57 year old female of Example 3 is experiencing an average of 1 .2 seizures per day at 6 months post dosing as stated in Example 3. The subject is administered low dose Eslicarbazepine acetate at 600mg/day; for 5 days cotimely with continued A19-144 administration daily at 2.0 mg for 5 days. No seizures are detected at 6 months post dosing. Cognitive testing detects no diminution of memory as compared with the subject prior to Eslicarbazepine acetate administration.
Example 5
Seizure Prophylaxis: A19-144 and Lacosamide
A 10 year old female is experiencing seizures 3.2 per day. The subject is administered lacosamide at 60mg two times per day for 5 days and cotimely
administration of A19-144 daily at 2.0 mg for 5 days. No seizures are detected at 6 months post dosing.
Example 6
Seizure Prophylaxis: A19-144 and Levetiracetam
The 9 year old female is experiencing an average of 3.3 seizures per day. The subject is administered Levetiracetam at 400mg two times per day for 5 days and cotimely administration of 3.0 mg of A19-144 daily for 5 days. No seizures are detected at 6 months post dosing. Cognitive testing detects no diminution of memory as compared with the subject prior to Levetiracetam administration.
The results of Examples 1 through 6 above are similarly effective when A2-73 is substituted for A19-144.
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