Anavex Life Sciences Corp (AVXL)

[GrassyKnoll]

The author of the Black Swan Nassim Taleb, has as one of his themes , that progress is largely incremental due to The accumulation of empirical evidence. He sites many cases where the theory follows the incremental empiricism.

One example is he gives ,if my memory is correct, is the development of the jet engine.

i have an insight to that particular observation. I My father in law had a very nice brass Christmas ornament. The device was powered by a candle that turned a small brass fan above it, that drove a device that rang a pleasant sounding bell.

The point is, empiricism is greatly underestimated in the study of scientific progress.

Some people just have to have a theory behind the observations, not that there is any thing wrong with that.

Now, if you look at the history of Anavex 273, it's discovery was largely experimental. Observations were previously made in the literature that the sigma one and muscaremic receptors were important. The receptor was extensively studied and somewhat elucidated. then some chemicals were chosen to fit to activate it. The structure of the chemicals were tinkered with, until 273 was found to work pretty ,pretty good on both. then 271 was found to be even better.

I do not know if any of this research progressed with a theoretical model for all the intricacies of regulation that the receptors are part of.