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VuBru

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VuBru

Re: james murphy post# 104882

Monday, 04/24/2017 1:28:47 PM

Monday, April 24, 2017 1:28:47 PM

Post# of 426389
James - The boss can say no stop, and expect no stop, but the stop is dependent on whether the results meet the criteria the company has given in advance to the DMC. If they had truly wanted no stop, they would not have given the DMC stopping rules with specific p values that are relatively easy to meet with a reasonable RRR. If there is a 25% RRR, p<.00001 for the PE, and all SEs are consistent, there is no advantage to going to completion.
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