Amarin Corp Plc (AMRN)

[oneragman]

Chas,
Good point on patient years. A couple of things:

Quote:"One subgroup could be less than stellar, or there could have been too many "soft" events."
-Even though a subgroup might be less than stellar, the DMC could determine that running the trial to completion will not change it's significance. Stroke is 12% at the 60% IA and 13% at 80%. Going to 100%(more time) will not really move the needle, but with 2 readings at 80%, you pretty much know where it will end up. Only if borderline and trending up or down would a particular SE affect a determination of whether to continue. A RRR of greater than 30% should leave few if any to be questionable.
-We don't know the breakdown between hard and soft Mace, but on a composite basis, AMRN does. This must not be a factor or they wouldn't be increasing inventory now.
-When looking at the JELIS graphs, I think of it as comparing 2 grams vs. 4 grams of EPA due to Japanese diet compared to 0 vs 4 in RI. The separation should be greater in RI.