Amarin Corp Plc (AMRN)

[VuBru]

HD and Raf - For the question being posed, the issue is not whether there is accelerating divergence between V and placebo over the whole trial (which does seem to be the case). The issue is whether there is significantly accelerating divergence between V and placebo arms between 3.5 years (80% IA) versus 4 years (100%). My opinion is there may be an increase, but likely small. I think AVI's recent point about narrowing of the confidence intervals with more events is the best argument for continuation. However, if there is a clinically meaningful and significant effect (and I think there will be), we should be seeing it by the 80% IA.