Anavex Life Sciences Corp (AVXL)

[GrassyKnoll]

The bigger picture.

Not only is sigma 1 ubiquitous and concentrated in every organ with intensive energy needs, but out there in the rest of the world, it is found in almost every animal.
It is also conserved accross many species, ancient and modern in evolutionary terms. That means that the sigma one found in a hotshot crab is almost the same as the one in AFs brain.and where to go and what to do.

What this means that it performs a very essential function, and it's evolution was essential to life.

Having a very long evolutionary. History,it has coevolved with exquisite feedback controls, and enabling regulatory and operational mechanisms.

Unfortunately, for us old farts, evolution does not favor aging. Once. One is past normal reproductive age, ones survival is irrelevant to evolution.
In fact, some theorize that there is evolutionary pressure encouraging aging and death after the age of reproduction and child rearing, as the old were a major. Drag on the tribal resources., or the resources of any other animal population.
That is why my x's guinea pig, Tow Truck, is all stroked out after only a few years.

So it is only natural that such a critical protein malfunctions in old age.
And , there is the miracle. Of systematic ,intelligent science. To discover. The receptor, and to systematically work to find ways to reactivate it.

One thing that I find remarkable is that many on this board are also heavily invested in a company that is in the clinical stage in the study. Of a highly conserved protein that is essential in the fidelity of cellular reproduction, and thus may play. An important part in the control of disease when that molecule. Is re activated.

Both companies are focused on exploiting the the cell's most important regulatory and repair mechanisms that essentially evolved eons ago.

all of the above is based. On my undergraduate level understanding of biology.
Just thought that we sometimes. Forget the really , really big picture.