Anavex Life Sciences Corp (AVXL)

[apostrophe]

re:"...Anavex Plus "

It "would have been nice" if donepizel had worked better (in combo patent with 2-73) because whoever is distributing it e.g. Aricept (Pfizer), could have become an ally of sorts, whereas now, the current SOC takes a minor sideline, or could pretty much be rendered obsolete. Not the best news for a donepizel-based medication maker.

Donepizel is primarily an acetylcholinesterase inhibitor. It's effect on receptors) was more-or-less accidental and is rather scatter-shot. It also picks up M2 and M3 which is undesirable and who knows what other receptors, which is why its side-effect profile isn't so hot and probably why it stops working after a while. imo

I believe M2 is part of the feedback mechanism to regulate/throttle-back acetylcholine production when it reaches a proper level, so after a while, agonizing M2 would ultimately render donepizel self-defeating. Also, since donepizel is in the bloodstream, areas outside the brain that didn't previously have an acetylcholine problem, for example, the heart, could be seen to suffer from having the regulation mechanism disrupted and thrown out of balance.

So, it might be just as well.