Amarin Corp Plc (AMRN)

[jessellivermore]

AVII77..

Thanks for posting..Small study, but surprisingly good good results..

The beneficial effects here might derive from EPA's ability to limit the area (volume) of tissue loss from the initial hypoxic insult..It is well known that in MIs and ischemic strokes the area of tissue damage extends out past the area of critical hypoxia...This is the result of "cytokines" which can trigger apoptosis in cells outside of the zone of critical hypoxia... This is why EPA may be useful also in head trauma and ischemic strokes..

Interestingly I had the chance to observe the effects of EPA on loss of skin and sub subcutaneous tissue in face lifts..Face lifts involve the creation of skin and underlying subcutaneous tissue flaps which put the circulation on stress. The stress is increased by cigarette smoking because of its effect on small blood vessels and reduction of the oxygen carrying capacity of the red blood cells..Patients are advised to stop smoking ten days before surgery and ten days after...But smokers will continue and will lie about it..So we do see loss of facial skin which is deforming and takes a long time to heal..I put all smokers on V 4ms/day before surgery and for a month after..V cut down the incidence of burn out areas" and dramatically shortened the time to wound resolution and extent of scarring...This was very impressive. Since the inflammatory system is cellular based it is reasonable that these cutaneous (and visable) effects are mirrored in the heart and the brain..After blood flow is stopped to the area.

":>) JL