Anavex Life Sciences Corp (AVXL)

[falconer66a]

Rats and mice validation is valid.

If this MOA works in humans the way it was proposed to work in mice according to Dr Maurice's research, 2-73 will be a great CNS therapy.

Yes, there is a copious pile of murine (rats and mice) studies showing safety and efficacies for Anavex drug candidates, particularly Anavex 2-73 (and still in the lab for Anavex 3-71).

Understandably, some might question the taking of an AVXL position based upon only good murine data, presently in the absence of proper Phase 3 human clinical results. Anavex will not be selling its products to treat rats with Alzheimer's; only humans.

As a biologist, I, too, would have this question, were Anavex 2-73 a conventional drug, treating non-CNS conditions. Are rat and mouse organ systems and biochemistries exactly parallel to those of humans? In some cases yes; others, no.

But for nerves and neurons, murine nervous systems and their componants, both at the organ and cellular levels, are almost exactly parallel. If Anavex 2-73 produces certain results in lab rats or mice, it has an extremely high chance to yield the same result(s) in humans --- as the existing Phase 2 data reveal.