Friday, February 24, 2017 6:02:05 PM
Of course. Everyone knows the INFO arm was not randomized. I certainly never said it was.
Comparing trials is fraught with problems. However, the IMUC trial did not screen for rapid progressors the same way the DCVax P3 trial did (giving rise to the INFO arm).
YOU were the one using the ICT-107 trial as a proxy for the DCVax P3 control arm. I simply noted, and reiterate, that if you do that, you need to realize the ICT-107 trial excluded patients like those found in the INFO arm.
And, while correcting for that, you have to realize the INFO arm survival numbers are reported from diagnosis (surgery) while the ICT-107 trial results are reported from a time point 13 weeks later. (I was wrong when I said 4 months, it is 13 weeks. But still requires consideration)
Below is a slide from the ICT-107 trial noting the P2 did NOT assess progression using MRI (but will for their P3).
(The red arrows are mine, the red "NOT" is theirs)
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