NorthWest Biotherapeutics Inc (NWBO)

[AVII77]

AVII you are correct, the 51 patients have a median OS of 18 months, now that is less than the 20-21 months of ICT-107.

No, their median was 14 months from the time where they would have been randomized (4 months after diagnosis/surgery).

In doing this thought experiment, we are trying to see how their inclusion in the ICT107 trial affected the observed 20-21 month median.

More than half of them evented before the 20 month mark.
less than half of them evented after the 20 month mark.

Had they been excluded, the median would not have been 20 months, it would have been more.

If you are familiar with the Will Rogers phenomenon it can be though of as:
Had the ICT107 trial removed these rapid progressors (the mix of ePD and psPD) and enrolled them in a rGBM trial, it would have increased the median of both of the two trials.

Actually, that would be a great example of the Will Rogers phenomena