Anavex Life Sciences Corp (AVXL)

[OFP]

Thanks, it certainly deserves scrutiny.

However, a word of caution on meta analysis like this, these 20 trials were for patient profiles that were all over the map.

(e.g. 45 years, 55, 75 years, varied baseline MMSE profiles, healthy individuals, mild, moderate, severe AD)

It is worth checking the Anavex methodology but my guess is they chose a sub set of this data which matched their patient profile and proved correlation with their statistical analysis. They likely went through the detail data of those 20 trials to find their SOC.

I'll dig up the meta study in my files but my guess is there may not be enough published about the methodology of either analysis to solve to our liking.

They were indeed for varying methods but were at least all for "mild-moderate" impairment. That being said, this is the group AVXL chose for comparison and what they based their claims on....as such we should at least be able to make sense of their findings.

Furthermore, I'd be shocked if they didn't also try to pull out some that were best matched for comparison....despite that they seem to have chosen to use the whole group anyway.