Amarin Corp Plc (AMRN)

[jfmcrr]

What I recall posting was about what can happen when trials stop early vs. not, with an example of a trial that could have stopped early with significance ending up being continued and being nonsignificant on completion.

Yup, I remember that post. I do also remember one where there was a substantial cost in lives to complete the trial. Maybe not your post. Or an acid flashback.Whatever. Thanks

My take on the ethics of an early stop of R-it is that this is an unusual case because V is already approved and available to anyone who wants it (potentially). Ethicists could argue that V as an effective treatment to reduce CV risk is not being withheld since it is already available, and therefore the ethical need to stop early for overwhelming efficacy is not as compelling, and must be balanced by the benefits to other patients (from greater strength of the secondary outcomes) if the trial is continued.

Toss in that the EPA/AA ratio that V achieves is also theoretically available through diet even if the drug is unavailable. A continued to completion trial will make my portfolio's eyes water more than it will make my ethical sense sting...