NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

This non-invasive method to identify mesenchymal based on MRI scan analysis sounds great. A non-invasive method is ideal, but this method would be for future use, not for analyzing accumulated MRI data for the trial. That is, unless they planned on this from way back. (The article is 2013) At least some of the scan types they describe are special scans, not just special post analysis.

New territory. What was the plan for Celldex's product for the classical group? Micro-array analysis to identify that subgroup? If agreed with the FDA, then that is the fall-back for NWBO on mesenchymal, if necessary. But to have a non-invasive method for full scale (after approval and ramp-up) patient screening would be fantastic. Hopefully the same method could give further identification beyond mesenchymal.

Then heterogeneity rears it's head. Maxwell Smart's Chaos. But sometimes they have to plod forward with imperfect models to make progress. Hopefully the subgrouping (4 subgroups) that they have done will be a useful enough model to allow progress.