NorthWest Biotherapeutics Inc (NWBO): Corrected: "48.84% Mesenchymal for GBM"...

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Doktornolittle

Re: Doktornolittle post# 101584

Thursday, 02/09/2017 7:44:00 PM

Thursday, February 09, 2017 7:44:00 PM

Corrected: "48.84% Mesenchymal for GBM"
(Article said GIMP Negative GBM 40% methylated... not all GBM.)

This number and other important stats must be highly radioactive because they have a very short half life in my brain. If so, maybe putting a critical mass of these stats in one place will evoke a brilliant flash of insight... like Jim on "Taxi" used to have.

Mesenchymal = 48.84% of GBM
Classical = 25.89% of GBM
Neural = 12.00% of GBM
Proneural = 13.26% of GBM

Mesenchymal = Predominantly unmethylated
Classical = Predominantly unmethylated
Neural = Predominantly unmethylated
Proneural = Methylated

GIMP Negative GBM (Mesenchymal+Classical+Neural) methylated: 40%
Inferred GBM overall methylated: 48%

Methylated GBM survival advantage with TMZ vs w/o TMZ: 6.4 months.
Unmethylated GBM survival advantage with TMZ vs w/o: 1 month.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995672/figure/pone-0094871-g004/

Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347445/
KeyChrt: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347445/figure/F1/

See also post Post # 101367 mostly replicated here.