I agree about the improvement in sleep being a huge benefit for caregivers, which is very important. I would add that not only does improved sleep also improve quality of life for the patients, both at night and during the day, there is a process for expelling mis-folded proteins from the cell that only occurs during a certain period of sleep. I wish I knew more about that. What I do know is that researchers have reported that at some point during sleep the brain cells contract dramatically, increasing the space between cells, then vibrate. This is believed to be a mechanism to expel large molecule waste that can't be broken down. Mis-folded proteins that have no corresponding enzyme matches for breakdown are shoved into the cell wall, and I believe wiggle on through the wall, exiting the cell during this shrinking and vibration. Alzheimer's may be the result of constipation in the brain, and A2-73 may be Ex-Lax for the brain as well as reducing the volume of this mis-folded protein waste to begin with.
I believe these findings are relatively new. Who knows what other strange things about the brain and about Alzheimer's will be learned in the future. But who cares why a given drug works if it works continuously and has no significant side effects. Patients like A2-73. That is meaningful all on it's own; again as long as whatever it is that they like lasts and has no significant side effects.
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I know this has been mentioned before but a hat tip anyway to Kyle76 for this in the comments section of a Seeking Alpha article.
"A little-discussed but, in my opinion, a key attribute that has been observed in A-273 testing is relief from insomnia, a very common and vexing symptom of many AD patients. Imagine the burden of a family member trying to care for someone who is up much of the night. Dealing with the many other symptoms of AD on little sleep has to be extremely difficult and probably leads to the institutionalization of many patients who might otherwise be treated at home. The promise of relief from this symptom alone is, to me, a huge factor in a medication that so far has shown few, if any, negative side effects."
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