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Thursday, January 26, 2017 5:58:59 PM
However, I kept thinking about it and realized that quality of life aside, the optimum administration would be 50:50 chance of the TMZ vs the cancer killing you. Something like that anyway.
However, the optimum level of TMZ when in conjunction with an immunotherapy would clearly be less than without the immunotherapy given that the way it kills you is that it destroys your immune system. So having a provision for SOC to be followed along with any new therapy being tested is counter intuitive if the therapy is an immunotherapy.
An example I sent to whoever might listen is the following: Say SOC was heating the tumor by 20 deg F with a small heater continuously for 6 months. But researchers want to test cooling the tumor by 20 deg F instead because it worked so well in rats. So the required protocol for the trial for the new treatment would be:
Control Arm: Heat the tumor by 20 deg F for 6 months.
Experimental Arm: Do nothing at all for 6 months.
So I hope RK is right that there is a limited dosing using TMZ. Not saying she is, but I hope she is.
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