Anavex Life Sciences Corp (AVXL)

[falconer66a]

Thank you for asking.

I have no particular knowledge of the neuropathic chemistry of Rett Syndrome, nor how the Anavex drug might be theraputic. The Anavex researchers clearly have investigated this and have very good reasons to believe efficacy can occur.

As in virtually every other human disease Anavex drugs will be tested for, the legitimacy of murine (mouse and rat) models to determine putative human efficacy comes into question. Mice are not men (well, people); but their nerve genetics and chemistries can be almost identical. Transgenic murines may be used, where the actual human genes of the relevant pathologies have been inserted into the genomes of the rats or mice being tested. Clinical results from these animals are extremely likely to be replicated in equivalent human trials, in people with the same genetic pathologies.