NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"99% of which is phagocytized at the injection site"

You had two primary points equating DCVax-L to a similar therapy that failed in trials. One was an overwhelming of the immune system, whether paths for DC travel to the lymph nodes, or crowding in the lymph nodes themselves. The other was this issue of the DC's being phagocytized at the injection site.

Let me ask you regarding that other study: Did they use the same "teenage" DC's? If not, there is no comparison regarding the ability of the DC's to avoid the macrophages. Macrophages are like sloths. Most DC's are like turtles, and vulnerable to sloths. Teenage DC's are like squirrels... no that's not it... they are like Jaguars! Yeaah! That's the ticket!

Regarding the overwhelming of the immune system: Northwest addressed this issue empirically by spreading the DC injections out over time and space (thank you Doc Logic). Did they do the same in this study that you often used as a comparison? It seems doubtful that they used the same process in this regard.