Anavex Life Sciences Corp (AVXL)

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No, dextromethorphan and donepezil are chemically and physiologically unrelated to Anavex’s molecules. Utterly different, with profoundly different and better outcomes for Anavex.

Dextromethorphan is a sedative, calming the overactive states of some Alzheimer’s patients. Incidental usage, failing to slow or stop symptomatic progression.

Donepezil, trade name Aricept, is a commonly used Alzheimer’s drug. It is an acetylcholinesterase inhibitor, promoting elevated levels of acetylcholine in nerves. This facilitates normalized nerve impulse transmission, so, for a period, mental activity is improved or stabilized — but only for a period, a few weeks or months only.

You ask, “Why will Anavex succeed where they have not?” Simple. Anavex will succeed because it successfully and chronically treats the real cause of Alzheimer’s, which is the presence of mis-folded, purely- or non-functioning enzyme proteins. Dextromethorphan is merely a sedative, with no useful chronic outcomes. Donepizil (Aricept) also fails to correct in any way protein misfolding. Anavex 2-73 does this, allowing normalized enzyme production, restoring normal nerve function.