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Re: Mikesc post# 83150

Saturday, 12/10/2016 2:53:47 PM

Saturday, December 10, 2016 2:53:47 PM

Post# of 465994
This looks like a shout out to Anavex and their trial design, no?

However, he said changes are needed in the design of clinical trials, especially for drugs intended to stop disease progression rather than treat symptoms. “Disease-modifying drugs act slowly and it’s hard to measure their effect, so selecting an optimal dose in a manageable sized trial is impossible,” he said. Consequently, sponsors have moved into large, costly, phase 3 (confirmatory) trials without knowing the correct dose. “I think that accounts for an enormous amount of failure over the last twenty years,” said Aisen.
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