a) The relative amount of insoluble a-beta vs soluble (I'd expect there to be a lot higher density of insoluble - so the sink would be disproportionate)
b) The rate constants that effect the conversion from insoluble to soluble. Given that it is plaque, I'd expect it to be 'sticky' - i.e a low rate constant.
I don't know either of the above parameters, but my question would be how confident are people that we do know those parameters?
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