Anavex Life Sciences Corp (AVXL)

[blu_1]

Donepezil has MUCH greater affinity for sigma receptors than does 273. So it occupies the majority of the receptor sites, I'm guessing, esp in the case of the patients on sub optimal doses of 273. If the patient was on donepezil for more than 3-6 months, it ain't doing much after that point in time. So, donepezil occupying most the sites, it ain't doing jack, and 273 is left just floating in space b/c the receptors are mostly occupied.