Anavex Life Sciences Corp (AVXL)

[blu_1]

***Revision of earlier post #80855***

Missling and Anavex have said for years 273 prevents the misfolding of amyloid! Misfolded amyloid is deemed a bad thing by Anavex, as it pertains to Alzheimers Disease.

What do enzymes have to do with Alzheimers Disease? I've never read that there has been any correlation between the two. I'm surmizing from what you wrote that you feel enzymes that were made with improper structure (b/c of faulty mito-er interaction) then in turn cause amyloid to be made (both normal amyloid and misfolded amyloid, both of which you say are waste products and not a good thing in the brain). So, if I follow your post, you feel that 273 acting on the sigma 1 receptors located on the er, will then restore proper interaction of mito-er, which then will result in enzymes made with proper structure (and thus, functionality). If enzymes are back to being made properly, the cell will not then be making waste proteins such as amyloid. Am I following you correctly? Is this just your hypothesis for what is going on, or is this what the Anavex scientists probably also assume is going on? If so, I wish Anavex would have elucidated this better to us. I wonder if this mechanism is how Anavex assumes 273 can return a cell to homeostasis?

Anavex has put forth a myriad of other reasons why their drug can help Alzheimers: its affect on Ca++, inflammation reduction, reduction of Tau tangles (I think this might be attributed to its action on the muscarinic receptors? or maybe sigma again?), and I forget the other benefits Anavex has mentioned in the past. ARE ALL THESE BENEFITS ATTRIBUTED TO 273 BINDING TO SIGMA 1 RECEPTORS ON THE ENDOPLASMIC RETICULUM (ER), OR TO BE MORE SPECIFIC, THE RER?

You mentioned the other companies' immunoglobulin drugs are too big to penetrate the blood brain barrier sufficiently to reduce amyloid. But Biogen's Aducanumab I thought has been shown to totally remove amyloid from Alzheimers patients brains based on PET scans. You said in last paragraph of your post "A beta tangles" but I think Tau tangles is the correct name?

Thank you falconer