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Friday, October 28, 2016 12:56:29 PM
Prins said they can get the t cells there and even activated in these patients, but they can't get extended survival in these patients.
He would know how these patients were responding to the vaccination from both the Info Arm and the EAP open label trial where all the rapid progressors go and immediately begin to receive the vaccination.
Now we know from the Info Arm data that the 20 double rapid progressors (those patients that by the time they began treatment, they had double the progression that would have rendered them ineligible to enter the main arm of the trial) showed a 15.3 median OS. And the median OS for rapid progressors is typically between 8.3 to 10.8 months. So a 15.3 median is definitely extending these patients' lives. But with this study linked below, Prins et al actually cured the mice using the combo of the DC Vaccine and the check point inhibitor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951098/
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