Avid Bioservices Inc (CDMO)

[jb_118]

BOT: If SK does indeed have evidence of “something that really takes place several days later that … leads to longer-term effects,”

This is what I was trying to elucidate from the Guinnea pig model data. At one day post treatment the pfu/ml had decreased compared to controls from just less than about 10^7 to just less than 10^6. By day six the difference was a little bigger (closer to 10^5 for Bavi). Then at some point half the pigs go to "virus free" state. Does clearance accelerate? I'd like to see the data.

Katie is right to point out that there's a leap between pigs with hemorrhagic fever and chronic HCV in humans. I should throw in the caveat that the pigs that eventually go "virus free" are the ones that lived. The viral titers at days 1 and 6 I assume are averages of the pigs treated with Bavi, some of whom won't respond. Would be interesting to know the viral loads at days 1 and 6 of the pigs who went on to clearance vs. bavi pigs who died.

Back to waiting for the human data.