Evaluate,
I stated almost from the start of my time on Seeking Alpha posts that my research led me to believe that NWBO had the best science to back their efforts as compared with rivals like CLDX, IMUC, STML and others and that they were on to a platform that could extend out well beyond cancer. That might be reason enough for secrecy and isolation all by itself. A little later I stated that mesenchymal genotype and phenotype, which occurs at progression even in non mesenchymal genotypes, was a critical part of understanding the correlation between effectiveness of the vaccine and the stratification of benefit in up to about 85% of patients based on the number of critical mesenchymal associated biomarkers found in each patient. This is why benefit will not be found in only mesenchymal genotype patients only but also in mesenchymal phenotype which most patient types morph into. Dr. Linda Liau has identified other treatments that might help unmethylated MGMT patients potentially find outcomes that rival some of those who have methylated MGMT. I am sure that she has freely shared this information with patients and doctors alike. As I became better informed about DC life cycle and subtypes, which play a critical role in understanding DCs beyond their APC role, I became more aware of the critual role that spacing of vaccines might play. flipper44 and I have had discussions about why crossover, low dose and increased dosing schedule should be helpful for this Phase 3 trial. Dr. Linda Liau's comments about all patients apparently living longer seem to confirm these thoughts when put in the context of trial expectations by a lead investigator. We won't know for sure that this is the case until enough information is shared but these comments were made within a specific research related context which create a certain level of added credibility value.
As I discussed with a doctor and their spouse tonight, sometimes the volume of general research remembered over the years helps me perceive things that specific research might confirm but does not necessarily make readily apparent in and of itself. Researchers often get bogged down in the specifics of actions and reactions and lose sight of the general context within which the specifics are enclosed. Those who step back from the table every once in a while seem to put observations into proper perspective a little better. Best wishes.
