Anavex Life Sciences Corp (AVXL)

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re: " If the results continue to be ambiguous,..."

They don't look ambiguous to me. I would characterize them as in-line / positive, what I expected, and should have resulted in a continued increase of perceived valuation, up to around the $8 level.

Sustained therapeutic effect after 31 weeks. That is better than anything else that exists. No cognitive decline below statistical error limits. It's still inside the bars.

I'm not a big fan of donepezil but it is the current soc, and it may be ok to "top-off the tank" on acetylcholine levels early on to give the patient a boost before it becomes counter-productive. I'm glad to see low dosage levels (5mg) on that. Also a one-way synergy is demonstrated in that 2-73 mitigates the donepezil side effects. But there is also indication that improvement continues without donepezil dragging 2-73 down after donepezil becomes ineffective and that patients should be taken off of it at that point.

Pessimistic articles are trying to attribute the remarkable improved functioning in some patients to simply feeling better temporarily from other ailments. Well, in the videos, the subjects appear to be in pretty good shape, it's not from that.

Now the same argument could be applied to the patients we don't see but we do know that many are "frail" and probably do suffer from other conditions like arthritis or prostate. They are already old and such ailments of old age tend to only get worse over time as they get even older. It is more likely that discomfort from those other things worsening could put downward pressure on a person's cognitive test scores. Also the weather (ie winter, cold, dampness) can aggravate joint problems and so forth.