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Tuesday, 08/09/2016 4:35:31 PM

Tuesday, August 09, 2016 4:35:31 PM

Post# of 462250
Very well written,informative post by Piotr on the Yahoo Conversation board---here is part of his post.......Even if somebody doubt A2-73 works the scores on the improvement in HAM-D scores shall dissipated this. In my opinion the different scores overlap somehow as they measure separate aspects of well being of the patients. I expect that improvement in MMSE and HAM-D shall sooner or later influences the ADCS-ADL scores, of course as sustained.
Another note on A2-73. The drug improving HAM-D scores points to use as treatment in depression. And what is more important it is not sedative. If efficacious against depression or psychosis this could be a blockbuster onto itself. The market for AD is 5 mil ppl but the market for depression is 14 mil ppl. The remark about not sedative aspect A2-73 can only be appeciated by a person who has taken that kind of drugs for which side effects are so strong that they lead to people dropping out from the treatment. The same applies to DZP where 50% patient drop out over the side effects.
A2-73 is not an instant cure but a new SOC of much better efficacy and lesser side effects. The sudden jump in MMSE score at 31 weeks for A2-73 only patients if sustained might bode well for real efficacy over longer period. From the data it can be seen that DZP at the least if not hurts then doesn't influence the course the disease, but it is obvious that it lowers the efficacy of A2-73 " to see the entire post go the the yahoo board
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