Anavex Life Sciences Corp (AVXL)

[falconer66a]

I’m not impressed with this new drug. For the few (and it will be a few — it only works [maybe] for a small fraction of Alzheimer’s patients who have an uncommon genotype), this could be a useful drug.

But, like so many others, it attempts to clear amyloid wastes from affected neurons, on the presumption that the amyloid masses are the direct cause of Alzheimer’s. Get rid of the amyloid masses and all should be well.

That’s not Anavex’s approach whatsoever. It is more enlightened, presuming that amyloid accumulations occur because of mitochondrial/endoplasmic reticulum disconnection and the consequent mis-folding of essential intra-neuron proteins this causes. That’s the root cause of Alzheimer’s, Parkinson’s, and large number (if not all) neurodegenerative diseases.

Wonderfully, Anavex 2-73 properly connects endoplasmic reticula with the mitochondria, so both organelles function normally, creating no amyloid or tau-tangle wastes.

Moreover, 2-73 works at low dosages, easily crosses the blood/brain barrier, and has demonstrated no adverse events (“side effects”) of any obviating consequence.

My money stays with Anavex.