Anavex Life Sciences Corp (AVXL)

[falconer66a]

There is abundant evidence that Anavex 2-73 restores and supports normal mitochondrial function, primarily by facilitating normalized junctions of the endoplasmic reticulum with the mitochondrion. Neurons (and other cells) can function normally when the ER connects properly to the mitochondrion. When they become disjointed, a host of neurodegenerative diseases occur (Alzheimer’s, Parkinson’s, Multiple Sclerosis, et. al).

A new report just appeared telling how mitochondrial dysfunction facilitates cancer. Although not directly implicating the sigma-1 molecule, the loss of normal mitochondrial function was determined to be a root factor in many cancers.

Now, all of the following is speculation, unsupported by any evidence.

There have been isolated references to 2-73 as a possible cancer therapy. If 2-73 can restore normalized mitochondrial function in cancer cells (as well as neurons), an entirely new, expansive mass of therapeutic applications might occur — effective treatment of many forms of cancer.

“...mitochondrial stress induces cancer-related metabolic shifts.”
(Unable to post the URL to this research, at the Univ. of Pennsylvania.)